American passenger train service:
Train service to Toronto for the severely irrational. But though Air Canada services the route, people who travel between those two places may be uncommon.
What about just zipping across the southern tier?
Holy three days and five hours, Batman! (Three days and seven hours with the time zones, actually.)
For comparison (both one-way), the bus takes 25 hours and costs $71.50 with advanced purchase. Google says it is a 16 hour drive.
Oops. It appears that the Gulf Coast route, though marked on the map, isn't in service at all.